the effect of melatonin on pediatric drug-resistant epilepsy; a randomized double blind clinical trial
Authors
abstract
backgroundabout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. melatonin is a natural pineal gland hormone. the use of melatonin for controlling pediatric seizures is still controversial. this study aimed to evaluate the effect of melatonin on seizures, parent's satisfaction, sleep, and behavior in children with drug-resistant epilepsy.materials and methods: in a pilot crossover study, children with drug-resistant epilepsy, who referred to the epileptic clinic of ghaem hospital, were randomly assigned to receive treatment with melatonin or a placebo for 4 weeks followed by a one-day washout period. then patients who started with melatonin were switched to the placebo. melatonin was administered 30 minutes before bedtime at a dose of 10 mg /m2 in 3mg tablets.resultstwenty patients, of which 11 (55%) were male, were enrolled into the study. the range and mean age of patients were 2 to 13 years and 7.28 ± 3.46 years, respectively. the mean number of diurnal seizures in the study group during placebo treatment was 11.05 and during melatonin treatment was 6.25, which was statistically significant (p=0.021). however, the reduction of the mean duration of diurnal seizures in the study groups was not statistically significant (p=0.386). there was no correlation between decreasing in number or duration of seizures with melatonin plasma levels. drowsiness was the only side effect of melatonin, which occurred in three patients. conclusionmelatonin has probable beneficial effects on some epileptic patients with unclear mechanisms. physicians can use it in selected epileptic children to improve seizures.
similar resources
The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial
BackgroundAbout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. Melatonin is a natural pineal gland hormone. The use of melatonin for controlling pediatric seizures is still controversial. This study aimed to evaluate the effect of melatonin on seizure...
full textThe Effect of Hydroxychloroquine on Symptoms of Knee Osteoarthritis: A Double-Blind Randomized Controlled Clinical Trial
Background: Osteoarthritis is a degenerative joint disorder of articular cartilage and is the most common type of arthritis in the elderly. There are only a few reports regarding the use of Hydroxychloroquine in the treatment of osteoarthritis. Methods: To investigate the effects of Hydroxychloroquine on the symptoms of mild to moderate knee osteoarthritis (Kellgren and Lawrence grade II and II...
full textEffect of Statin Treatment on COVID-19 Patients’ Outcomes: A Randomized Double-blind Controlled Clinical Trial
Background: Statins may be protective against viral infection and have been suggested for the treatment of coronavirus disease 2019 (COVID-19). Objective: In this study, we aimed to evaluate the effect of atorvastatin on COVID-19 patients. Methods: Our study is a randomized double-blind controlled clinical trial that constitutes a population of COVID-19 patients admitted to Bu-Ali Sina Hospi...
full textEffect of acupressure on constipation in patients undergoing hemodialysis: A randomized double-blind controlled clinical trial
Objective: Constipation is one of the most common digestive problems in patients undergoing hemodialysis. It has a negative effect on quality of life in these patients. As routine treatments are not effective in this regard, complementary therapies may help to overcome this condition. This study aimed to investigate the effect of acupressure on constipation in patients undergoing hemodialysis. ...
full textComparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial
Background: Intracerebral Hemorrhage (ICH) is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH. Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH. Materials and Methods: This double-blind clinical trial was conducted in an academic hospital in northern Iran on patient...
full textMelissa officinalis effect on female sexual dysfunction: a double blind, randomized clinical trial
Background and objectives: Female sexual dysfunction is a very common health problem that affects 25-65% of women. Melissa officinalis or lemon balm (Lamiaceae) has been reported in folk medicine for treatment of nervous debility, so this study was designed to evaluate the efficacy of M. officinalis to improve female libido. Methods: Eighty ni...
full textMy Resources
Save resource for easier access later
Journal title:
international journal of pediatricsجلد ۴، شماره ۱۱، صفحات ۳۸۹۷-۳۹۰۶
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023